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KMID : 1037020190080020064
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Medical Lasers; Engineering, Basic Research, and Clinical Application
2019 Volume.8 No. 2 p.64 ~ p.73
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The Effectiveness of 448-kHz Capacitive Resistive Monopolar Radiofrequency for Subcutaneous Fat Reduction in a Porcine Model
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Kwon Tae-Rin
Lee Sung-Eun
Kim Jong-Hwan
Jeon Yong-Jae
Jang You-Na
Yoo Kwang-Ho
Kim Beom-Joon
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Abstract
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Background and Objectives: The effectiveness of many physiotherapy modalities in reducing subcutaneous fat has been investigated in numerous previous studies. However, to the best of our knowledge, there have been no attempts to determine the effectiveness of physiotherapy modalities in body contouring. The present report determined the effect of 448-kHz capacitive resistive monopolar radiofrequency (CRMRF) in a porcine model.
Materials and Methods: This study investigated the effect of selective destruction of the subcutaneous fat layer in abdominal fat tissue using CRMRF. The effects of two types of CRMRF (capacitive electric transfer (CET) and resistive electric transfer (RET)) treatment were evaluated using regular digital photography in addition to thermal imaging evaluation, ultrasound measurement, hematological evaluation, and histologic analyses (H&E (hematoxylin and eosin), Oil red O, and immunohistochemistry staining).
Results: Preclinical evaluation was performed to obtain the data for comparison of the safety and efficacy of the subcutaneous fat reduction after applying CRMRF using CET and RET. After treatment, the thermal transmission was effective, and a 42-47°C temperature change was observed in the fat layer while an approximately temperature of 42°C was confirmed on the skin surface. Moreover, after the application of both types of CRMRF treatment, fibrotic septa were observed in the adipose tissue induced by heat at the treatment sites. TUNEL staining was also performed to confirm the process of apoptosis in the adipocytes.
Conclusion: These results suggest that both CET and RET for CRMRF treatment are safe and effective for subcutaneous fat reduction in a porcine model.
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KEYWORD
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Radiofrequency, Hyperthermia, Cellular biostimulation, Subcutaneous fat reduction, Apoptosis
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